To Get From Downtown Orlando To 1307 Shepherd Ave, Sanford, Fl: Head Northeast On W South St Toward S Orange Ave. Turn Left Onto S Orange Ave. Use The Left 2 Lanes To Turn Left Onto W Colonial Dr. Merge Onto I-4 E Via The Ramp To Daytona Beach. Keep Left At The Fork To Stay On I-4 E, Follow Signs For Daytona Beach. Take Exit 101B For Fl-46 Toward Sanford/Mount Dora. Keep Right At The Fork, Follow Signs For Fl-46 W And Merge Onto Fl-46 W. Continue Straight Onto W 1St St. Turn Left Onto S Mellonville Ave. Turn Right Onto W 13Th St. Turn Left Onto S Palmetto Ave. Turn Right Onto W 14Th St. Turn Left Onto Shepherd Ave. The Destination, 1307 Shepherd Ave, Sanford, Fl, Will Be On The Right. This Route Covers Approximately 27 Miles And Takes Around 30-40 Minutes Depending On Traffic Conditions.